11/12/2022 0 Comments Iunit weight of kindling![]() Especially the DG region where the adult neurogenesis occurs has been associated with various pathophysiological events including cognitive dysfunctions. This structure consists of different subunits such as the cornu ammonis (CA) and the dentate gyrus (DG). The hippocampus is a part of the limbic system in the brain that performs many tasks such as learning, memory, location, and emotional behavior. Our results indicate that the chronic administration of NP-OTs may have positive effects on hippocampal damage via increasing neurogenesis and decreasing apoptosis and seizure severity. A significant increase of neurogenesis and decrease of apoptosis in the hippocampus of the PTZ + NP-OT group were observed, while OTs and NP-OTs had protective effects against PTZ-induced damage to hippocampal neurons. SWMET-related behaviors were also recovered in the PTZ + NP-OT group. We showed that OTs and NP-OTs prevented the kindling development and had positive effects on seizure severity. Serum total antioxidant status (TAS) and total oxidant status (TOS) levels and the oxidative stress index (OSI) were measured. Hippocampus histopathology, neurogenesis, and apoptosis were demonstrated. A spatial working memory evaluation test (SWMET) was performed after the last injection. Then, seizure severity (score and latency) was calculated for the PTZ groups. Consequently, saline and PTZ were injected, respectively, 25 times every 48 h. Saline/OT/NP-OTs were administrated to both control (Ctrl) and PTZ groups intranasally. The aim of this study is to investigate the effects of IN administration of chronic NP-OTs on the hippocampus of PTZ-induced male epileptic rats in terms of seizure severity, memory, neurogenesis, and neuronal damage. However, there are very limited data on epilepsy research about oxytocin-loaded nanoparticles (NP-OTs). Although the intranasal (IN) administration of oxytocin (OT) has limited efficiency, nanoparticles (NPs) are a promising candidate to deliver OT to the brain. Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |